Return to IndexRev Clin Periodoncia Implantol Rehabil Oral. 2009;2:86-90
REVISIÓN BIBLIOGRÁFICA [PDF
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Linfocitos T Reguladores y Periodontitis
Regulatory T Cells and Periodontal Disease
Carré L1, Dutzan N2, Lavandero S3, Gamonal J4
1Cirujano-Dentista, Alumna Magister en Cs. Odontológicas mención Periodontología, Laboratorio de Biología Periodontal, Facultad de Odontología, Universidad de Chile. Chile.
2Cirujano-Dentista, Magister en Cs. Odontológicas mención Periodontología, Profesor asistente Área de Periodoncia, Laboratorio de Biología Periodontal, Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile. Chile.
3Químico Farmacéutico, Doctor en Bioquímica, Profesor Titular, Centro de Estudios Moleculares de la Célula, Facultad de Cs. Químicas y Farmacéuticas, Universidad de Chile. Chile.
4Cirujano-Dentista, Especialista en Periodoncia, Magister y Doctor en Cs. Odontológicas, Director del Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile. Chile.
Resumen
La enfermedad periodontal requiere de un hospedero susceptible para su desarrollo y progresión. Dentro de las características del hospedero se encuentra la respuesta de células T reguladoras, que proveen de tolerancia frente antígenos propios, pero a la vez, participa durante las enfermedades infecciosas y tumorales como mecanismos de evasión de la respuesta inmune efectora. En infecciones virales, parasitarias y bacterianas se ha visto que los linfocitos T reguladores (Tregs) generan la persistencia de la infección en el tiempo y son responsables de muchos de los cambios patológicos de estas. Investigaciones recientes en enfermedad periodontal indican que se encuentran presentes en gran cantidad, pero su rol en la patogénesis de la enfermedad se encuentra en estudio. Esta revisión muestra los resultados de los estudios publicados en el área de periodoncia, que señalan una posible asociación entre los Tregs y la infección periodontal.
Palabras clave: Linfocitos T reguladores, periodontitis, tolerancia.
Abstract
Periodontal disease requires a susceptible host for it´s development and progression. One of the characteristics of the host is the regulatory response that give tolerance against own antigens , but at the same time, is used during infectious and tumoral diseases as a mechanism of evasion of the immune response. In viral, parasitic and bacterial infections regulatory T cells (Tregs) cause persistence of the infection, and they are responsible of many of the pathologic changes. Recent investigations in periodontal disease show that Tregs are present in a great quantity, but it´s role is in current study. This review shows the results of published studies in periodontics that lead to a possible association between Tregs and periodontal infection.
Key words: Regulatory T cells, periodontal disease, tolerance.
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